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BioLiP

Structure of PDB 1z6j Chain H

Receptor sequence
>1z6jH (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY
RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLR
APFP
3D structure
PDB1z6j Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa.
ChainH
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA H E70 D72 E75 H76 E80 E58 D60 E63 H64 E68
BS02 PY3 H H57 C58 D60 G97 T98 D189 S190 C191 K192 S195 S214 W215 G216 G219 C220 H41 C42 D44 G85 T86 D186 S187 C188 K189 S192 S211 W212 G213 G215 C216 MOAD: ic50=0.0094uM
PDBbind-CN: -logKd/Ki=8.03,IC50=0.0094uM
BindingDB: IC50=9.4nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1z6j, PDBe:1z6j, PDBj:1z6j
PDBsum1z6j
PubMed15913999
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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