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BioLiP

Structure of PDB 7mt9 Chain G

Receptor sequence
>7mt9G (length=346) Species: 9913 (Bos taurus) [Search protein sequence]
LETVVANSAFIAARGSFDAMGEDWFLDFRVLGRGGFGEVFACQMKATGKL
YACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAYAFETKTDLCL
VMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIY
RDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLL
GEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRVLEQAVTY
PDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWRQLEA
GMLTPPFVPDSRTVYAKNIQDVGAFSTVKGVAFEKADTEFFQEFAS
3D structure
PDB7mt9 Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
ChainG
Resolution7.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D314 K316 E318 N319 D332 A341 T352
Catalytic site (residue number reindexed from 1) D152 K154 E156 N157 D170 A179 T190
Enzyme Commision number 2.7.11.14: rhodopsin kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SGV G L193 G194 V201 A214 M264 M267 L321 L31 G32 V39 A52 M102 M105 L159
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G protein-coupled receptor kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0050254 rhodopsin kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0009966 regulation of signal transduction
GO:0016310 phosphorylation
GO:0022400 regulation of opsin-mediated signaling pathway
GO:0046777 protein autophosphorylation
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042995 cell projection
GO:0097381 photoreceptor disc membrane

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Cellular Component
External links
PDB RCSB:7mt9, PDBe:7mt9, PDBj:7mt9
PDBsum7mt9
PubMed34262173
UniProtP28327|GRK1_BOVIN Rhodopsin kinase GRK1 (Gene Name=GRK1)

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