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BioLiP

Structure of PDB 5zop Chain G

Receptor sequence
>5zopG (length=383) Species: 9606 (Homo sapiens) [Search protein sequence]
FTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECI
RGRKATLEELQTVHSEAHTLLYGTNPSVFVRLPCGGVGVDSDTIWNEVHS
AGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNS
VAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDD
GNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMP
IASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGR
IVLALEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSM
EKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCEN
3D structure
PDB5zop Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4.
ChainG
Resolution2.698 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide G D759 F812 G868 N869 F870 F871 P872 P942 D92 F145 G201 N202 F203 F204 P205 P275
BS02 ZN G D840 H842 D934 D173 H175 D267
BS03 ZN G C667 C669 H675 C751 C16 C18 H24 C84
External links
PDB RCSB:5zop, PDBe:5zop, PDBj:5zop
PDBsum5zop
PubMed30321390
UniProtP56524|HDAC4_HUMAN Histone deacetylase 4 (Gene Name=HDAC4)

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