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Structure of PDB 9ava Chain F

Receptor sequence
>9avaF (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
LPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTVPPPPR
VVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFL
RRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKAL
EKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHA
RPFGTIRPMYG
3D structure
PDB9ava Co-crystal structure of human TREX1 in complex with an inhibitor
ChainF
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AG1 F D18 A21 G23 L24 I84 H124 Y129 D130 L133 D13 A16 G18 L19 I72 H112 Y117 D118 L121
BS02 A1AG1 F E83 I84 E71 I72
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:9ava, PDBe:9ava, PDBj:9ava
PDBsum9ava
PubMed
UniProtQ9NSU2|TREX1_HUMAN Three-prime repair exonuclease 1 (Gene Name=TREX1)

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