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Structure of PDB 5cb4 Chain F

Receptor sequence

>5cb4F (length=334) Species: 9031 (Gallus gallus)

MYTFVVRDENSSVYAEVSRLLLATGQWKRLRKDNPRFNLMLGERNRLPFG
RLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELSESCTWFPESYVI
YPTDEREVFLAAYNRRREGREGNVWIALISSEASELLDFIDEQGQVHVIQ
KYLEKPLLLEPGHRKFDIRSWVLVDHLYNIYLYREGVLRTSSEPYNSANF
QDKTCHLTNHCIQKNYGRYEEGNEMFFEEFNQYLMDALNTTLENSILLQI
KHIIRSCLMCIEPAISTKHLHYQSFQLFGFDFMVDEELKVWLIEVNGAPA
CAQKLYAELCQGIVDVAISSVFPLATSIFIKLHH

3D structure

• PDB: 5cb4 Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery.
• Chain: F
• Resolution: 2.193 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ACP	F	K74 Q183 Y185 L186 T241 N242 D318 I330 E331	K74 Q150 Y152 L153 T208 N209 D281 I293 E294

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sun May 18 04:09:55 2025

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1709                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1710         else:

=> 1711             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1712     

   1713     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '5cb4', asym_id = 'F', title = 'Structures of a diverse set of colchicine bindin...h tubulin provide a rationale for drug discovery.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='5cb4', asym_id='F', title='Structures of a diverse set of colchicine bindin...h tubulin provide a rationale for drug discovery.')

    843 

    844     if go:

=>  845         display_go(go,uniprot,pdbid,asym_id)

    846     return pubmed,uniprot

    847 

global display_go = <function display_go>, go = '0036211', uniprot = '', pdbid = '5cb4', asym_id = 'F'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0036211', uniprot='', pdbid='5cb4', asym_id='F')

    484         '''.replace("$namespace_link",namespace_link

    485           ).replace("$namespace",namespace

=>  486           ).replace("$uniprot",u

    487         ))

    488         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>