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BioLiP

Structure of PDB 5c08 Chain F

Receptor sequence
>5c08F (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAP
WIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYG
CDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAA
HVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEAT
LRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP
SGQEQRYTCHVQHEGLPKPLTLRWEP
3D structure
PDB5c08 Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
ChainF
Resolution2.332 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide F Y7 M45 E63 K66 V67 H70 T73 D77 Y84 R97 Y99 Y116 T143 W147 L156 Y159 W167 Y171 Y7 M45 E63 K66 V67 H70 T73 D77 Y84 R97 Y99 Y116 T143 W147 L156 Y159 W167 Y171
External links
PDB RCSB:5c08, PDBe:5c08, PDBj:5c08
PDBsum5c08
PubMed27183389
UniProtP04439|HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (Gene Name=HLA-A)

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