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BioLiP

Structure of PDB 8r4q Chain E

Receptor sequence
>8r4qE (length=315) Species: 9606 (Homo sapiens) [Search protein sequence]
RIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIF
REVQIMKMLSHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMA
EKEARRKFKQIVTAVYFCHSRNIVHRDLKAENLLLDANLNIKIADFGFSN
LFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGAL
PFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQI
CKHKWMKLGDADPNFDRLIAESQQPLNEDVLLAMEDMGLDKEQTLQSLRS
DAYDHYSAIYSLLCD
3D structure
PDB8r4q The structures of salt inducible kinase 3 in complex with pharmacological inhibitors reveal determinants for binding and selectivity.
ChainE
Resolution2.838 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DB8 E R70 I72 A93 K95 I126 T142 Y144 A145 G148 E149 L195 R9 I11 A32 K34 I65 T81 Y83 A84 G87 E88 L134
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8r4q, PDBe:8r4q, PDBj:8r4q
PDBsum8r4q
PubMed38508313
UniProtQ9Y2K2|SIK3_HUMAN Serine/threonine-protein kinase SIK3 (Gene Name=SIK3)

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