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Structure of PDB 2q3e Chain E

Receptor sequence

>2q3eE (length=459) Species: 9606 (Homo sapiens)

FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLP
IYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKG
RAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPN
LNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEH
WVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEV
ATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQ
QVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSI
YISKYLMDEGAHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACDG
AHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGF
QIETIGKKV

3D structure

• PDB: 2q3e Structure and mechanism of human UDP-glucose 6-dehydrogenase.
• Chain: E
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): T131 E165 K220 N224 C276 D280
• Catalytic site (residue number reindexed from 1): T130 E164 K219 N223 C275 D279
• Enzyme Commision number: 1.1.1.22: UDP-glucose 6-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAI	E	I10 G11 G13 V15 D36 V37 R41 V89 N90 T91 Y108 S130 T131 E161 L163 E165 C276 K279 R346	I9 G10 G12 V14 D35 V36 R40 V88 N89 T90 Y107 S129 T130 E160 L162 E164 C275 K278 R345
BS02	UPG	E	F162 L163 A164 E165 K220 I231 F265 K267 S269 F272 G273 C276 F277 F338 K339 R442	F161 L162 A163 E164 K219 I230 F264 K266 S268 F271 G272 C275 F276 F337 K338 R435

Gene Ontology

Molecular Function

• GO:0003979 UDP-glucose 6-dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0042802 identical protein binding
• GO:0051287 NAD binding

Biological Process

• GO:0001702 gastrulation with mouth forming second
• GO:0006024 glycosaminoglycan biosynthetic process
• GO:0006065 UDP-glucuronate biosynthetic process
• GO:0015012 heparan sulfate proteoglycan biosynthetic process
• GO:0030206 chondroitin sulfate biosynthetic process
• GO:0034214 protein hexamerization
• GO:0048666 neuron development

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005829 cytosol
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:2q3e, PDBe:2q3e, PDBj:2q3e
• PDBsum: 2q3e
• PubMed: 21502315
• UniProt: O60701|UGDH_HUMAN UDP-glucose 6-dehydrogenase (Gene Name=UGDH)

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