Structure of PDB 2j4j Chain E

Receptor sequence
>2j4jE (length=216) Species: 273057 (Saccharolobus solfataricus P2) [Search protein sequence]
MNIILKISGKFFDEDNVDNLIVLRQSIKELADNGFRVGIVTGGGSTARRY
IKLAREIGIGEAYLDLLGIWASRLNAYLVMFSLQDLAYMHVPQSLEEFIQ
DWSHGKVVVTGGFQPGQSTAAVAALVAEASSSKTLVVATNVDGVYEKDPR
IYADVKLIPHLTTQDLRKILEELLDPLAIKIVERSKIRVIVMNYRKLNRI
IDILKGEEVSSIIEPV
3D structure
PDB2j4j Structural and Enzymatic Investigation of the Sulfolobus Solfataricus Uridylate Kinase Shows Competitive Utp Inhibition and the Lack of GTP Stimulation
ChainE
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.22: UMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO E Y88 H104 Y88 H104
BS02 U5P E G42 D65 G68 I69 G112 F113 Q114 Q117 S118 T119 G42 D65 G68 I69 G112 F113 Q114 Q117 S118 T119
BS03 ACP E K6 S8 G9 K10 G44 R48 T139 N140 Y145 K147 D148 P149 L183 K6 S8 G9 K10 G44 R48 T139 N140 Y145 K147 D148 P149 L173
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0009041 UMP/dUMP kinase activity
GO:0016301 kinase activity
GO:0033862 UMP kinase activity
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006225 UDP biosynthetic process
GO:0016310 phosphorylation
GO:0044210 'de novo' CTP biosynthetic process
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:2j4j, PDBe:2j4j, PDBj:2j4j
PDBsum2j4j
PubMed17297917
UniProtQ97ZE2|PYRH_SACS2 Uridylate kinase (Gene Name=pyrH)

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