BioLiP

Structure of PDB 7miz Chain D6

Receptor sequence

>7mizD6 (length=428) Species: 5811 (Toxoplasma gondii) [Search protein sequence]

MREVISIHVGQAGIQIGNACWELFCLEHGIQPDGQMPDAFNTFFSETGAG
KHVPRCVFLDLEPTVVDEVRTGTYRHLFHPEQLISGKEDAANNFARGHYT
IGKEIVDLSLDRIRKLADNCTGLQGFLMFNAVGGGTGSGLGCLLLERLSV
DYGKKSKLNFCSWPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAI
YDICRRNLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDVTEFQTNL
VPYPRIHFMLSSYAPIISAEKAYHEQLSVAEITNSAFEPASMMAKCDPRH
GKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQP
PTVVPGGDLAKVMRAVCMISNSTAIAEVFSRMDHKFDLMYAKRAFVHWYV
GEGMEEGEFSEAREDLAALEKDYEEVGI

3D structure

PDB

7miz Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins.

Chain

Resolution

3.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D6	N18 A19 E22 L26 G29 P37 E77 T225 R229 P364	N18 A19 E22 L26 G29 P37 E68 T216 R220 P355
BS02	GTP	D6	G10 Q11 A12 D98 N101 A140 G144 T145 G146 T179 N206 Y224 N228	G10 Q11 A12 D89 N92 A131 G135 T136 G137 T170 N197 Y215 N219

Gene Ontology

	Molecular Function
GO:0005200	structural constituent of cytoskeleton
GO:0005525	GTP binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

	Biological Process
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0007017	microtubule-based process

	Cellular Component
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005874	microtubule

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:7miz, PDBe:7miz, PDBj:7miz
PDBsum	7miz
PubMed	34031406
UniProt	P10873\|TBA_TOXGO Tubulin alpha chain