BioLiP

Structure of PDB 8isn Chain D

Receptor sequence

>8isnD (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]

GSHSMRYFSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAP
WIEQEGPEYWDEETGKVKAHSQTDRENLRIALRYYNQSEAGSHTLQMMFG
CDVGSDGRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQITKRKWEAA
HVAEQQRAYLEGTCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEAT
LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP
SGEEQRYTCHVQHEGLPKPLTLRW

3D structure

PDB

8isn Elucidation of binding mechanism, affinity, and complex structure between mWT1 tumor-associated antigen peptide and HLA-A*24:02.

Chain

Resolution

2.48 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	Y7 E63 K66 V67 H70 T73 N77 I80 Y84 M97 F99 H114 T143 K146 W147 Q156 Y159 T163	Y7 E63 K66 V67 H70 T73 N77 I80 Y84 M97 F99 H114 T143 K146 W147 Q156 Y159 T163

External links

PDB	RCSB:8isn, PDBe:8isn, PDBj:8isn
PDBsum	8isn
PubMed	37661929
UniProt	D9UAY1

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