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Structure of PDB 7s4g Chain D

Receptor sequence

>7s4gD (length=218) Species: 9606 (Homo sapiens)

DIVMTQSPDSLAVSLGERATINCKSSQSLLLSGNQENYLAWHQQKPGQPP
KTLITWASTRISGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQSYSA
PYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREA
KVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYAC
EVTHQGLSSPVTKSFNRG

3D structure

• PDB: 7s4g Novel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer.
• Chain: D
• Resolution: 2.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	Y38 W56 S97 Y98 S99 Y102	Y38 W56 S97 Y98 S99 Y102
BS02	peptide	D	L31 G33	L31 G33

External links

• PDB: RCSB:7s4g, PDBe:7s4g, PDBj:7s4g
• PDBsum: 7s4g
• PubMed: 35364611

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