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BioLiP

Structure of PDB 6o0j Chain D

Receptor sequence
>6o0jD (length=532) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
PSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVR
IDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIV
LSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAERTSALNATWRSA
TCRVLAAATGARTANAGPVHFDIPLRVTPPGRPAGKPWTYTPPVTFDQPL
DIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLR
PQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRA
VTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRP
GDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAY
EGAHERTGPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGG
GIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGP
TLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL
3D structure
PDB6o0j Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis.
ChainD
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.9: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DNA D Y95 R97 R277 R303 W304 Y93 R95 R259 R285 W286
BS02 MG D D440 D469 G471 D418 D447 G449
BS03 TPP D S377 N378 G403 I404 D405 G439 D440 L441 T442 D469 G471 G472 G473 I474 F475 S359 N360 G385 I386 D387 G417 D418 L419 T420 D447 G449 G450 G451 I452 F453
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016740 transferase activity
GO:0030145 manganese ion binding
GO:0030976 thiamine pyrophosphate binding
GO:0046872 metal ion binding
GO:0070204 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:6o0j, PDBe:6o0j, PDBj:6o0j
PDBsum6o0j
PubMed32029475
UniProtP9WK11|MEND_MYCTU 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (Gene Name=menD)

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