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BioLiP

Structure of PDB 6l9m Chain D

Receptor sequence
>6l9mD (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
AGPHSMRYFETAVSRPGLGEPRYISVGYVDNKEFVRFDSDAENPRYEPQA
PWMEQEGPEYWERITQIAKGQEQWFRVNLRTLLGYYNQSAGGTHTLQWMY
GCDVGSDGRLLRGYEQFAYDGCDYIALNEDLKTWTAADMAAQITRRKWEQ
AGAAEYYRAYLEGECVEWLHRYLKNGNATLLRTDSPKAHVTHHPRSKGEV
TLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVV
PLGKEQNYTCRVYHEGLPEPLTLRWEPP
3D structure
PDB6l9m Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer.
ChainD
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D Y7 Y45 R62 I63 I66 Q70 W73 N77 L81 Y84 W97 Y99 F116 T143 K146 W147 A152 Y155 Y156 Y159 W167 Y171 Y8 Y46 R63 I64 I67 Q71 W74 N78 L82 Y85 W98 Y100 F117 T144 K147 W148 A153 Y156 Y157 Y160 W168 Y172
External links
PDB RCSB:6l9m, PDBe:6l9m, PDBj:6l9m
PDBsum6l9m
PubMed34074778
UniProtP01897|HA1L_MOUSE H-2 class I histocompatibility antigen, L-D alpha chain (Gene Name=H2-L)

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