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BioLiP

Structure of PDB 6dmu Chain D

Receptor sequence
>6dmuD (length=607) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
WEQYRDRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAV
GETALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQ
NLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEEI
VRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHQSL
ELVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHVQWTCGPLTSTLYDLTE
IDSWGEELSFLELVVSSKKREARQILEQTPVKELVSFKWKKYGRPYFCVL
ASLYILYMICFTTCCIYRPLKLRDDNRTDPRDITILQQKLLQEAYVTHQD
NIRLVGELVTVTGAVIILLLEIPDIFRVGASRYFGQTILGGPFHVIIITY
ASLVLLTMVMRLTNMNGEVVPLSFALVLGWCSVMYFARGFQMLGPFTIMI
QKMIFGDLMRFCWLMAVVILGFASAFHITFQTEDPNNLGEFSDYPTALFS
TFELFLTIIDGPANYSVDLPFMYCITYAAFAIIATLLMLNLFIAMMGDTH
WRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGYEYGLGDRWFLR
VENHHDQ
3D structure
PDB6dmu Structural insights on TRPV5 gating by endogenous modulators.
ChainD
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PIO D R302 F416 Q418 R270 F384 Q386
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005516 calmodulin binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0035809 regulation of urine volume
GO:0051289 protein homotetramerization
GO:0055074 calcium ion homeostasis
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0098703 calcium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Cellular Component
External links
PDB RCSB:6dmu, PDBe:6dmu, PDBj:6dmu
PDBsum6dmu
PubMed30305626
UniProtQ9XSM3|TRPV5_RABIT Transient receptor potential cation channel subfamily V member 5 (Gene Name=Trpv5)

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