Structure of PDB 2pvy Chain D

Receptor sequence
>2pvyD (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
ELPEDPKWEFPRDKLTLGKPLQVVMAEAVGIDKDKPKEAVTVAVKMLKDD
ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL
REYLRARRPPGVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARN
VLVTENNVMKIADFGLARDINNIDYYKNTTNGRLPVKWMAPEALFDRVYT
HQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNE
LYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT
3D structure
PDB2pvy A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
ChainD
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D626 A628 R630 N631 D644
Catalytic site (residue number reindexed from 1) D145 A147 R149 N150 D163
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP D L487 A515 Y566 A567 N571 L633 L21 A43 Y94 A95 N99 L152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2pvy, PDBe:2pvy, PDBj:2pvy
PDBsum2pvy
PubMed17803937
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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