BioLiP

Structure of PDB 2j4j Chain D

Receptor sequence

>2j4jD (length=216) Species: 273057 (Saccharolobus solfataricus P2) [Search protein sequence]

MNIILKISGKFFDEDNVDNLIVLRQSIKELADNGFRVGIVTGGGSTARRY
IKLAREIGIGEAYLDLLGIWASRLNAYLVMFSLQDLAYMHVPQSLEEFIQ
DWSHGKVVVTGGFQPGQSTAAVAALVAEASSSKTLVVATNVDGVYEKDPR
IYADVKLIPHLTTQDLRKILEELLDPLAIKIVERSKIRVIVMNYRKLNRI
IDILKGEEVSSIIEPV

3D structure

PDB

2j4j Structural and Enzymatic Investigation of the Sulfolobus Solfataricus Uridylate Kinase Shows Competitive Utp Inhibition and the Lack of GTP Stimulation

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.4.22: UMP kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CO	D	Y88 H104	Y88 H104
BS02	U5P	D	G42 D65 G68 I69 G112 F113 Q114 Q117 S118 T119	G42 D65 G68 I69 G112 F113 Q114 Q117 S118 T119
BS03	ACP	D	K6 S8 G9 K10 G44 R48 T139 N140 Y145 D148 P149 R150 E182	K6 S8 G9 K10 G44 R48 T139 N140 Y145 D148 P149 R150 E172

Gene Ontology

	Molecular Function
GO:0005524	ATP binding
GO:0009041	UMP/dUMP kinase activity
GO:0016301	kinase activity
GO:0033862	UMP kinase activity

	Biological Process
GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0006225	UDP biosynthetic process
GO:0016310	phosphorylation
GO:0044210	'de novo' CTP biosynthetic process
GO:0046940	nucleoside monophosphate phosphorylation

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

PDB	RCSB:2j4j, PDBe:2j4j, PDBj:2j4j
PDBsum	2j4j
PubMed	17297917
UniProt	Q97ZE2\|PYRH_SACS2 Uridylate kinase (Gene Name=pyrH)