BioLiP

Structure of PDB 8gio Chain C

Receptor sequence

>8gioC (length=340) Species: 10090 (Mus musculus) [Search protein sequence]

DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNT
GSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFPLSHFVLS
ATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDI
ILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKQGETWRLS
FSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELD
AFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLD
HYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK

3D structure

PDB

8gio Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 0.1mM Mn2+

Chain

Resolution

2.67 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	T334 K335 T338	T176 K177 T180
BS02	dna	C	R222 K315	R75 K157
BS03	dna	C	R158 L159 K160 R161 K184 K395	R11 L12 K13 R14 K37 K229
BS04	dna	C	R161 S165 Y200 K372	R14 S18 Y53 K206
BS05	ATP	C	G198 S199 E211 D213 R364 S368 E371 K402 S420 Y421	G51 S52 E64 D66 R198 S202 E205 K236 S254 Y255
BS06	ZN	C	H378 C385 C392	H212 C219 C226
BS07	MN	C	S199 E211 D213	S52 E64 D66
BS08	MN	C	E211 D213 D307	E64 D66 D149

External links

PDB	RCSB:8gio, PDBe:8gio, PDBj:8gio
PDBsum	8gio
PubMed	38740774
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

[Back to BioLiP]

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417