Structure of PDB 8dc4 Chain C

Receptor sequence
>8dc4C (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
MSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTSTYSPALNKLFCQLAKTCP
VQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERSSDSDGLAPPQ
HLIRVEGNLRVEYLDDRNTFRHSVVVPCEPPEVGSDSTTIHYNYMCYSSC
MGGMNRRPILTIITLEDSSGNLLGRDSFEVRVSASPGRDRRTEEENL
3D structure
PDB8dc4 A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability.
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C176 H179 C242 C84 H87 C150
BS02 R3R C L145 W146 V147 T150 C220 E221 P222 P223 D228 T230 L53 W54 V55 T58 C128 E129 P130 P131 D136 T138
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dc4, PDBe:8dc4, PDBj:8dc4
PDBsum8dc4
PubMed36197521
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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