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Structure of PDB 8cdj Chain C

Receptor sequence
>8cdjC (length=702) Species: 9606 (Homo sapiens) [Search protein sequence]
LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSAQFVGLELYKR
LKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLN
RHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKER
NGETINTRLISGVVQSYVELGLTLTVYKESFESQFLADTERFYTRESTEF
LQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLE
IFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAA
IEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGR
FINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMV
VFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYT
SKLQRMFQDIGVSKDLNEQFKKHLFSIQVLSSGSWPFQQFALPSELERSY
QRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQ
YNDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLVELKPDTLIKLYLG
YKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKV
LKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSY
LA
3D structure
PDB8cdj Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
ChainC
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C F535 S536 I537 Q538 V539 L540 S541 G576 R577 K578 L579 T580 W581 L582 S586 K587 G588 F475 S476 I477 Q478 V479 L480 S481 G513 R514 K515 L516 T517 W518 L519 S523 K524 G525
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0030674 protein-macromolecule adaptor activity
GO:0031625 ubiquitin protein ligase binding
GO:0160072 ubiquitin ligase complex scaffold activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006915 apoptotic process
GO:0008283 cell population proliferation
GO:0009887 animal organ morphogenesis
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936 protein K48-linked ubiquitination
GO:0097193 intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0019005 SCF ubiquitin ligase complex
GO:0031461 cullin-RING ubiquitin ligase complex
GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:8cdj, PDBe:8cdj, PDBj:8cdj
PDBsum8cdj
PubMed37028429
UniProtQ13616|CUL1_HUMAN Cullin-1 (Gene Name=CUL1)

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