Structure of PDB 7yxr Chain C

Receptor sequence

>7yxrC (length=245) Species: 32644 (unidentified) [Search protein sequence]

EFPTLISLLEVIEPEVLASGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKW
AKALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDL
VINEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPK
DGLKSQAVFDEIRMTYIKELGKAIVKRSQNWQRFYQLTKLLDSMHEMVGG
LLQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQ

3D structure

PDB

7yxr The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities.

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	K579 L589 M593 Q597 E755 N759	K52 L62 M66 Q70 E224 N228
BS02	DEX	C	L563 N564 Q570 M601 M604 F623 Q642 C736 T739	L36 N37 Q43 M74 M77 F96 Q115 C205 T208

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity
GO:0034056	estrogen response element binding

	Biological Process
GO:0006357	regulation of transcription by RNA polymerase II
GO:0030518	nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7yxr, PDBe:7yxr, PDBj:7yxr
PDBsum	7yxr
PubMed	36464162
UniProt	A0A1X8XLE9

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