BioLiP

Structure of PDB 6wh4 Chain C

Receptor sequence

>6wh4C (length=375) Species: 562,9606 [Search protein sequence]

LHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAI
ADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCA
ISLDRYVAIQNHSRFNSRTKAFLKIIAVWTISVGISMPIPVFQDDSKVFK
EGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWE
TLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPDSPEMKDFRHGF
DILVGQIDDALKLKVKEAQAAAEQLKTTRNAYIQKYLTMQSISNEQKACK
VLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYASS
AVNPLVYTLFNKTYRSAFSRYIQCQ

3D structure

PDB

6wh4 Structure of a Hallucinogen-Activated Gq-Coupled 5-HT 2A Serotonin Receptor

Chain

Resolution

3.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	89F	C	W151 D155 V156 S159 L229 S242 W336 F340	W83 D87 V88 S91 L156 S169 W313 F317
BS02	CLR	C	Y394 I395	Y371 I372
BS03	NDS	C	N1011 Y1101 K1104	N203 Y282 K285

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0004993	G protein-coupled serotonin receptor activity
GO:0005506	iron ion binding
GO:0009055	electron transfer activity
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0022900	electron transport chain

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0042597	periplasmic space

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:6wh4, PDBe:6wh4, PDBj:6wh4
PDBsum	6wh4
PubMed
UniProt	P0ABE7\|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC); P28223\|5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (Gene Name=HTR2A)