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BioLiP

Structure of PDB 6v6q Chain C

Receptor sequence
>6v6qC (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAV
KMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLFVIVEF
ASKGNLREFLRARRPPGMEEQMTFKDLVSCTFQLARGMEFLASQKCIHRD
LAARNVLVTENNVMKIADFGLARDIGRLPVKWMAPEALFDRVYTHQSDVW
SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELFMMMR
DCWHAVPSQRPTFKQLVEDLDRILTLTTN
3D structure
PDB6v6q The combined action of the intracellular regions regulates FGFR2 kinase activity
ChainC
Resolution2.46 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D626 R630 N631 D644
Catalytic site (residue number reindexed from 1) D150 R154 N155 D168
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP C L487 A515 E565 F566 A567 L633 D644 L21 A49 E99 F100 A101 L157 D168
BS02 MG C N631 D644 N155 D168
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6v6q, PDBe:6v6q, PDBj:6v6q
PDBsum6v6q
PubMed
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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