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Structure of PDB 6rr0 Chain C

Receptor sequence

>6rr0C (length=115) Species: 4932 (Saccharomyces cerevisiae)

NLSKSSWRQEWLANLKLISVSLVDEFPSELSDSDRQIINEKMQLLKDIFA
NNLKSAISNNFRESDIIILKGEIEDYPMSSEIKIYYNELQNKPKKARFWS
FMKTQRFVSNMGFDI

3D structure

• PDB: 6rr0 The Sir4 H-BRCT domain interacts with phospho-proteins to sequester and repress yeast heterochromatin.
• Chain: C
• Resolution: 2.18 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	L969 K971 W974 E977 W978 I985 D1032 R1066 W1068 K1072 R1075 N1079	L2 K4 W7 E10 W11 I18 D65 R97 W99 K103 R106 N110

External links

• PDB: RCSB:6rr0, PDBe:6rr0, PDBj:6rr0
• PDBsum: 6rr0
• PubMed: 31515872
• UniProt: P11978|SIR4_YEAST Regulatory protein SIR4 (Gene Name=SIR4)

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