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BioLiP

Structure of PDB 5dws Chain C

Receptor sequence
>5dwsC (length=40) Species: 9606 (Homo sapiens) [Search protein sequence]
LPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQ
3D structure
PDB5dws Crystal Structure of ITCH WW3 domain in complex with TXNIP peptide
ChainC
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R447 Y455 V457 H459 R462 T464 Q465 W466 R13 Y21 V23 H25 R28 T30 Q31 W32
External links
PDB RCSB:5dws, PDBe:5dws, PDBj:5dws
PDBsum5dws
PubMed
UniProtQ96J02|ITCH_HUMAN E3 ubiquitin-protein ligase Itchy homolog (Gene Name=ITCH)

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