BioLiP

Structure of PDB 4j2x Chain C

Receptor sequence

>4j2xC (length=421) Species: 10090 (Mus musculus) [Search protein sequence]

PPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLM
GSGWKKKKEQMETDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAK
TLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKN
ADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLLD
DDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDA
DDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGA
SWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQ
NFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPV
TLVRNDGVIYSTSLTFTYTPE

3D structure

PDB

4j2x Structure and Function of the CSL-KyoT2 Corepressor Complex: A Negative Regulator of Notch Signaling.

Chain

Resolution

2.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	P338 P340 K341	P286 P288 K289
BS02	peptide	C	G234 N235 F236 E259 E260 F261 T262 V263 D265 V277 G282 M283 A284 P286 I332 Q333	G182 N183 F184 E207 E208 F209 T210 V211 D213 V225 G230 M231 A232 P234 I280 Q281
BS03	dna	C	K84 Y86 S191 K196 R220 Q222	K32 Y34 S139 K144 R168 Q170	PDBbind-CN: Kd=0.011uM
BS04	dna	C	K90 R91 F92 K192 K195 R218 S221 T223 K311	K38 R39 F40 K140 K143 R166 S169 T171 K259	PDBbind-CN: Kd=0.011uM

Gene Ontology

	Molecular Function
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006357	regulation of transcription by RNA polymerase II

	Cellular Component
GO:0005634	nucleus

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:4j2x, PDBe:4j2x, PDBj:4j2x
PDBsum	4j2x
PubMed	24290140
UniProt	P31266\|SUH_MOUSE Recombining binding protein suppressor of hairless (Gene Name=Rbpj)