Structure of PDB 4hfz Chain C

Receptor sequence
>4hfzC (length=92) Species: 9606 (Homo sapiens) [Search protein sequence]
SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRL
YDAAQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLV
3D structure
PDB4hfz The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant.
ChainC
Resolution2.694 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C L54 G58 I61 M62 Y67 Q72 H73 V93 K94 H96 Y100 L38 G42 I45 M46 Y51 Q56 H57 V77 K78 H80 Y84
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4hfz, PDBe:4hfz, PDBj:4hfz
PDBsum4hfz
PubMed23897459
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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