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BioLiP

Structure of PDB 3zm7 Chain C

Receptor sequence
>3zm7C (length=346) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
GLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLE
DGGVEVADDGRGIPVATHASGIPTVDVVMTQLVGVSVVNALSTRLEVEIK
RDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETV
ARRLQEMAFLNKGLTINLTDERKVKSRTFHYPGGLVDFVKHINRTKNAIH
SSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRS
ALTSVVNKYAKDRKLLKDPNLTGDDIREGLAAVISVKVSEPQFETKTKLG
NTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAARK
3D structure
PDB3zm7 Mycobacterium Tuberculosis DNA Gyrase ATPase Domain Structures Suggest a Dissociative Mechanism that Explains How ATP Hydrolysis is Coupled to Domain Motion.
ChainC
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP C E48 N52 E56 G83 I84 V123 G124 V125 E27 N31 E35 G62 I63 V83 G84 V85
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:3zm7, PDBe:3zm7, PDBj:3zm7
PDBsum3zm7
PubMed24015710
UniProtP9WG45|GYRB_MYCTU DNA gyrase subunit B (Gene Name=gyrB)

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