Structure of PDB 3h52 Chain C

Receptor sequence
>3h52C (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
MLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVK
WAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPD
LIINEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVP
KDGLKSQALFDAIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMH
EVVENLLNYCFQTFAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB3h52 Molecular switch in the glucocorticoid receptor: active and passive antagonist conformations
ChainC
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 486 C L563 G567 Q570 W600 F623 M639 L37 G41 Q44 W74 F97 M113 BindingDB: IC50=1.1nM,Ki=1.2nM,EC50=872nM,Kd=15nM
External links
PDB RCSB:3h52, PDBe:3h52, PDBj:3h52
PDBsum3h52
PubMed19913032
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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