Structure of PDB 2jkv Chain C

Receptor sequence
>2jkvC (length=482) Species: 9606 (Homo sapiens) [Search protein sequence]
AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTK
VVGAQSLKEMVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDG
GNSEYRDTTRRCRDLKAKGILFVGSGVSGGEEGARYGPSLMPGGNKEAWP
HIKTIFQGIAAKVGTGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEA
YHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANILKFQDTDGKHLL
PKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQAS
KKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGW
TLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVEN
CQDSWRRAVSTGVQAGIPMPCFTTALSFYDGYRHEMLPASLIQAQRDYFG
AHTYELLAKPGQFIHTNWTGHGGTVSSSSYNA
3D structure
PDB2jkv Structure of Human Phosphogluconate Dehydrogenase in Complex with Nadph at 2.53A
ChainC
Resolution2.532 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S129 K184 H187 N188 E191
Catalytic site (residue number reindexed from 1) S128 K183 H186 N187 E190
Enzyme Commision number 1.1.1.44: phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C G451 S478 S479 G450 S477 S478
BS02 NAP C A12 V13 M14 N33 R34 T35 K38 L74 V75 K76 A80 G102 N103 A11 V12 M13 N32 R33 T34 K37 L73 V74 K75 A79 G101 N102
Gene Ontology
Molecular Function
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006098 pentose-phosphate shunt
GO:0009051 pentose-phosphate shunt, oxidative branch
GO:0019322 pentose biosynthetic process
GO:0019521 D-gluconate metabolic process
GO:0046177 D-gluconate catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2jkv, PDBe:2jkv, PDBj:2jkv
PDBsum2jkv
PubMed
UniProtP52209|6PGD_HUMAN 6-phosphogluconate dehydrogenase, decarboxylating (Gene Name=PGD)

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