Structure of PDB 2az5 Chain C

Receptor sequence
>2az5C (length=129) Species: 9606 (Homo sapiens) [Search protein sequence]
DKPVAHVVANPQAEGQLQWLNLLANGVELRDNQLVVPSEGLYLIYSQVLF
KGQGCPSTHVLLTHTISRIAVTKVNLLSAIKSPCPWYEPIYLGGVFQLEK
GDRLSAEINRPDYLDFAESGQVYFGIIAL
3D structure
PDB2az5 Small-molecule inhibition of TNF-alpha.
ChainC
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 307 C L57 Y119 L120 G121 G122 Y151 L43 Y91 L92 G93 G94 Y123 MOAD: ic50=22uM
BindingDB: Kd=5360nM,IC50=1300nM
Gene Ontology
Molecular Function
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2az5, PDBe:2az5, PDBj:2az5
PDBsum2az5
PubMed16284179
UniProtP01375|TNFA_HUMAN Tumor necrosis factor (Gene Name=TNF)

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