Structure of PDB 1o5w Chain C

Receptor sequence

>1o5wC (length=512) Species: 10116 (Rattus norvegicus)

AGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEH
VKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFR
GAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKD
LIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFS
VTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETL
NHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVY
YKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKAD
RLAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTA
YFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREV
LNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVST
SVALLCFVLYKI

3D structure

• PDB: 1o5w Structure of rat monoamine oxidase a and its specific recognitions for substrates and inhibitors.
• Chain: C
• Resolution: 3.2 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): G2071 R2206 K2305
• Catalytic site (residue number reindexed from 1): G62 R197 K296
• Enzyme Commision number: 1.4.3.21: primary-amine oxidase.
  1.4.3.4: monoamine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	C	I2019 G2022 S2024 E2043 A2044 R2045 G2050 R2051 G2066 G2067 A2068 Y2069 P2243 V2244 I2273 W2397 Y2402 C2406 Y2407 G2434 T2435 G2443 Y2444 M2445	I10 G13 S15 E34 A35 R36 G41 R42 G57 G58 A59 Y60 P234 V235 I264 W388 Y393 C397 Y398 G425 T426 G434 Y435 M436
BS02	MLG	C	I2180 F2208 Q2215 C2323 I2325 I2335 T2336 Y2407 Y2444	I171 F199 Q206 C314 I316 I326 T327 Y398 Y435	BindingDB: IC50=2050nM,Ki=1200nM

Gene Ontology

Molecular Function

• GO:0008131 primary methylamine oxidase activity
• GO:0016491 oxidoreductase activity
• GO:0050660 flavin adenine dinucleotide binding
• GO:0051378 serotonin binding
• GO:0052595 aliphatic amine oxidase activity
• GO:0097621 monoamine oxidase activity

Biological Process

• GO:0006584 catecholamine metabolic process
• GO:0009967 positive regulation of signal transduction
• GO:0042420 dopamine catabolic process
• GO:0042424 catecholamine catabolic process
• GO:0042428 serotonin metabolic process
• GO:0042443 phenylethylamine metabolic process

Cellular Component

• GO:0005739 mitochondrion
• GO:0005741 mitochondrial outer membrane

External links

• PDB: RCSB:1o5w, PDBe:1o5w, PDBj:1o5w
• PDBsum: 1o5w
• PubMed: 15050826
• UniProt: P21396|AOFA_RAT Amine oxidase [flavin-containing] A (Gene Name=Maoa)