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Structure of PDB 1n8r Chain C

Receptor sequence

>1n8rC (length=237) Species: 2238 (Haloarcula marismortui)

GRRIQGQRRGRGTSTFRAPSHRYKADLEHRKVEDGDVIAGTVVDIEHDPA
RSAPVAAVEFEDGDRRLILAPEGVGVGDELQVGVDAEIAPGNTLPLAEIP
EGVPVCNVESSPGDGGKFARASGVNAQLLTHDRNVAVVKLPSGEMKRLDP
QCRATIGVVGGGGRTDKPFVKAGNKHHKMKARGTKWPNVRGVAMNAVDHP
FGGGGRQHPGKPKSISRNAPPGRKVGDIASKRTGRGG

3D structure

• PDB: 1n8r Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit
• Chain: C
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	C	G1 R2 R3 G6 Q7 R8 R9 G10 R11 G12 T13 S14 T15 R17 A18 S20 H21 Y23 K24 A25 D26 K31 H47 P49 R51 S52 S111 G113 K117 F118 A119 R120 A121 S122 G123 V124 L140 P141 S142 E144 K146 G162 G163 R164 T165 K167 P168 F169 V170 K171 A172 G173 K175 H176 H177 K178 G183 T184 K185 W186 P187 N188 V189 R190 G191 V192 M194 N195 A196 V197 D198 G203 G204 R206 Q207 H208 G210 K211 P212 K213 S214 I215 S216 R217 N218 P220 P221 G222 R223 K224 V225 G226 D227 I228 A229 S230 K231 R232 T233 G234 R235 G236	G1 R2 R3 G6 Q7 R8 R9 G10 R11 G12 T13 S14 T15 R17 A18 S20 H21 Y23 K24 A25 D26 K31 H47 P49 R51 S52 S111 G113 K117 F118 A119 R120 A121 S122 G123 V124 L140 P141 S142 E144 K146 G162 G163 R164 T165 K167 P168 F169 V170 K171 A172 G173 K175 H176 H177 K178 G183 T184 K185 W186 P187 N188 V189 R190 G191 V192 M194 N195 A196 V197 D198 G203 G204 R206 Q207 H208 G210 K211 P212 K213 S214 I215 S216 R217 N218 P220 P221 G222 R223 K224 V225 G226 D227 I228 A229 S230 K231 R232 T233 G234 R235 G236

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:1n8r, PDBe:1n8r, PDBj:1n8r
• PDBsum: 1n8r
• PubMed: 12860128
• UniProt: P20276|RL2_HALMA Large ribosomal subunit protein uL2 (Gene Name=rpl2)

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