BioLiP

Structure of PDB 1hgg Chain C

Receptor sequence

>1hggC (length=328) Species: 132504 (Influenza A virus (A/X-31(H3N2))) [Search protein sequence]

QDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGK
ICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPY
DVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSR
LNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTNQEQTSLYVQASG
RVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGN
LIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKI
TYGACPKYVKQNTLKLATGMRNVPEKQT

3D structure

PDB

1hgg Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GAL	C	W222 G225	W222 G225
BS02	SIA	C	Y98 G135 S136 N137 W153 H183 E190 S228	Y98 G135 S136 N137 W153 H183 E190 S228
BS03	BGC	C	S95 Y100	S95 Y100
BS04	SIA	C	E89 Y105 R109 R269	E89 Y105 R109 R269

Gene Ontology

	Molecular Function
GO:0046789	host cell surface receptor binding

	Biological Process
GO:0019064	fusion of virus membrane with host plasma membrane

	Cellular Component
GO:0019031	viral envelope

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:1hgg, PDBe:1hgg, PDBj:1hgg
PDBsum	1hgg
PubMed	1327122
UniProt	P03437\|HEMA_I68A0 Hemagglutinin (Gene Name=HA)