BioLiP

Structure of PDB 1bd3 Chain C

Receptor sequence

>1bd3C (length=224) Species: 5811 (Toxoplasma gondii) [Search protein sequence]

QEESILQDIITRFPNVVLMKQTAQLRAMMTIIRDKETPKEEFVFYADRLI
RLLIEEALNELPFQKKEVTTPLDVSYHGVSFYSKICGVSIVRAGESMESG
LRAVCRGVRIGKILIQRDETTAEPKLIYEKLPADIRERWVMLLDPMCATA
GSVCKAIEVLLRLGVKEERIIFVNILAAPQGIERVFKEYPKVRMVTAAVD
ICLNSRYYIVPGIGDFGDRYFGTM

3D structure

PDB

1bd3 Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding.

Chain

Resolution

1.93 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	R137 T141 D235 D238
Catalytic site (residue number reindexed from 1)	R117 T121 D215 D218
Enzyme Commision number	2.4.2.9: uracil phosphoribosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PO4	C	R137 A168 T169 A170 G171 S172	R117 A148 T149 A150 G151 S152
BS02	PO4	C	R129 R158	R109 R138

Gene Ontology

	Molecular Function
GO:0004845	uracil phosphoribosyltransferase activity
GO:0005525	GTP binding
GO:0016757	glycosyltransferase activity

	Biological Process
GO:0044206	UMP salvage

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:1bd3, PDBe:1bd3, PDBj:1bd3
PDBsum	1bd3
PubMed	9628859
UniProt	Q26998\|UPP_TOXGO Uracil phosphoribosyltransferase (Gene Name=uprt)