BioLiP

Structure of PDB 9at2 Chain B

Receptor sequence

>9at2B (length=346) Species: 9606 (Homo sapiens) [Search protein sequence]

LIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWE
LDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALD
FNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEEN
ELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFI
RIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRAL
QGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSK
SGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLEH

3D structure

PDB

9at2 Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.

Chain

Resolution

2.25 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	A1AF5	B	Y42 Y45	Y3 Y6
BS02	HEM	B	F72 H76 Y79 S151 G152 F153 F158 R159 Y175 W324 H328 V332 Y350 L351	F33 H37 Y40 S112 G113 F114 F119 R120 Y136 W285 H289 V293 Y305 L306
BS03	ZIQ	B	R103 E105 W208 R211 T212 P213 F304	R64 E66 W169 R172 T173 P174 F265
BS04	A1AF5	B	F72 H76 R144 S148 P149 A150	F33 H37 R105 S109 P110 A111

External links

PDB	RCSB:9at2, PDBe:9at2, PDBj:9at2
PDBsum	9at2
PubMed	39106326
UniProt	P48775\|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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