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Structure of PDB 8ev1 Chain B

Receptor sequence
>8ev1B (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEPFSEASMMGLLTNLADRELVHMINWA
KRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLD
RNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTF
LKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIR
HMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB8ev1 Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors.
ChainB
Resolution1.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 E380 D538 L539 E542 I47 K51 L61 E69 D223 L224 E227
BS02 WVW B M343 T347 E353 M421 M528 M32 T36 E42 M110 M213
External links
PDB RCSB:8ev1, PDBe:8ev1, PDBj:8ev1
PDBsum8ev1
PubMed36516582
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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