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Structure of PDB 8ei9 Chain B

Receptor sequence
>8ei9B (length=86) Species: 9606 (Homo sapiens) [Search protein sequence]
ETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB8ei9 Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides
ChainB
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B M50 L54 L57 I61 M62 Y67 Q72 V93 K94 Y100 M26 L30 L33 I37 M38 Y43 Q48 V69 K70 Y76
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:8ei9, PDBe:8ei9, PDBj:8ei9
PDBsum8ei9
PubMed37914719
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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