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BioLiP

Structure of PDB 7xyz Chain B

Receptor sequence
>7xyzB (length=456) Species: 10090 (Mus musculus) [Search protein sequence]
LLRQELSCPLCLQLFDAPVTAECGHSFCRACLIRVAGEPAADGTVACPSC
QAPTRPQALSTNLQLSRLVEHCEEHLDPLSIYCEQDRTLVCGVCASLGSH
RGHRLLPAAEAQARLKTQLPQQKMQLQEASMRKEKTVAVLEHQLVEVEET
VRQFRGAVGEQLGKMRMFLAALESSLDREAERVRGDAGVALRRELSSLNS
YLEQLRQMEKVLEEVADKPQTEFLMKFSLVTSRLQKILSESPPPARLDIQ
LPVISDDFKFQVWKHMFRHLMPALEELTFDPSSAHPSLVVSSSGRRVECS
DQKAPPAGEDTRQFDKAVAVVAQQLLSQGEHYWEVEVGDKPRWALGVMAA
DASRRGRLHAVPSQGLWLLGLRDGKILEAHVEAKEPRALRTPERPPARIG
LYLSFADGVLAFYDASNPDVLTPIFSFHERLPGPVYPIFDVCWHDKGKNA
QPLLLV
3D structure
PDB7xyz Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane.
ChainB
Resolution4.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C14 C17 C34 C37 C8 C11 C28 C31
BS02 ZN B C29 H31 C56 C23 H25 C50
BS03 ZN B H89 C108 H75 C94
BS04 ZN B C97 D100 H114 H117 C83 D86 H100 H103
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
GO:0031624 ubiquitin conjugating enzyme binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0001778 plasma membrane repair
GO:0003012 muscle system process
GO:0006887 exocytosis
GO:0006900 vesicle budding from membrane
GO:0007517 muscle organ development
GO:0010832 negative regulation of myotube differentiation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0051260 protein homooligomerization
Cellular Component
GO:0005886 plasma membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0042383 sarcolemma

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Cellular Component
External links
PDB RCSB:7xyz, PDBe:7xyz, PDBj:7xyz
PDBsum7xyz
PubMed37770719
UniProtQ1XH17|TRI72_MOUSE Tripartite motif-containing protein 72 (Gene Name=Trim72)

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