BioLiP

Structure of PDB 7kjc Chain B

Receptor sequence

>7kjcB (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]

GPGDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTKK
EVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMM
IITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRD
LAARNILVNSNLVCKVSDFGPIRWTAPEAISYRKFTSASDVWSFGIVMWE
VMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERA
RRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTPFRTVSEWLES
IKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGL

3D structure

PDB

7kjc Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker.

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D739 A741 R743 N744 D757 P780
Catalytic site (residue number reindexed from 1)	D150 A152 R154 N155 D168 P171
Enzyme Commision number	2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ACP	B	I619 E623 V627 A644 K646 M695 L746 D757	I33 E37 V41 A55 K57 M106 L157 D168

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

PDB	RCSB:7kjc, PDBe:7kjc, PDBj:7kjc
PDBsum	7kjc
PubMed	34857764
UniProt	P29317\|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)