Structure of PDB 6l37 Chain B

Receptor sequence

>6l37B (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]

TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCM
AEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFAN
LDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRK
PFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEK
MQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKK
TESDAALHPLLQEIYRDMY

3D structure

PDB

6l37 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.

Chain

Resolution

2.91 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GW9	B	I241 C276 T279 V332	I42 C77 T80 V133
BS02	GW9	B	A250 E251 L254 C275 A333 Y334	A51 E52 L55 C76 A134 Y135
BS03	GW9	B	L254 K257 N261 H274 C275 C278 A455 L456 H457	L55 K58 N62 H75 C76 C79 A256 L257 H258
BS04	C5F	B	F273 Q277 S280 Y314 H440 I447 A455	F74 Q78 S81 Y115 H241 I248 A256	BindingDB: EC50=900nM

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6l37, PDBe:6l37, PDBj:6l37
PDBsum	6l37
PubMed	33205029
UniProt	Q07869\|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

[Back to BioLiP]

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417