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Structure of PDB 6co7 Chain B

Receptor sequence
>6co7B (length=1061) Species: 45351 (Nematostella vectensis) [Search protein sequence]
FTPLYDGGDSSHVHLNKFSRRECIRFVPKCTTKHPTNAYGEIDFEGYGGQ
KRAPYLRMSHDTDANLVITLMLKRWNLEIPNLVISVTGGAKSFVLKPRLR
EMFRRGLIKAAKTTGAWIITGGTNTGVMKHVGEAVKEQQLMFGSDTQVNV
IGIATWGIVDKQSDLISEKNGKYPALYSMEPTPGHQGAMLDPNHSHFFLV
DDGTEGKYGVEIGMRSRIEEAIMKVKTDSRSEAGSIGVPVVLLVLEGGPN
TVATMYELIKKKVPAVVIDGSGRAASVVGFAYNHTIKRNVDGQTINVIDP
QYEDEVRAKVVEVFGAKGADKTYSMIKDVLEDEKMISVYSLDGEISQDID
LAILKALLKANRSSPVAQLNLALAWNRIDLAKSDIFTEEQQWTTETLSAA
MLTALLDDKAEFAELFLQNGLSMREFLSLDILCKLYAEVPGNTTIKPLLQ
KEMGKRQVKTIDMDVVGEVIEELMGDMFESYYRKDGHYFGIDPLPTPYLD
VFLWAVLCNRRELARVLWEAGREPMAAALMASRLLKRMASRAQEDNTITD
ISSDLYDHARLFEERAVGVLDECFNENETLSQTLLVRELDHYSRMTALEL
AVSAESQDFIAHTSCQVLLTRLWMGTMAMNTRWWKVLVCLYLPVLIFPII
YFVPDEQHERQAAEREHQKSLNQDDSMEVIMRNKKLGFCDRIMHFYSAPF
SKFVGNVVGYLAFIFLYAYVVLFNFPRFDPAKTLGGIHPTEIVLYFWVFT
ILIEEIRQLAAKPPKYIKDKVSVYFSDTWNFVDIFSLTVFIIAIILRFFT
NSRIFTASRIILSLDIIFFIVRSLQIFSVNRLLGPKLVMIQKMMQDLAQF
IIILAVFTIAYGIALHAVMFPSPGIYARNNTWVTITSVVQYPYWQMYGEL
FLDEIQGEKPKEFGEVDPDGRWLSPLLLAIYMVFTNILLLNLLIAIFNYT
FERVQEDSDKVWKFQRYDLVQEYHSRPVFAPPLVLLGHILIFIRWVWRTM
KIGLSPAEMEQMDNWEFQAAEMYIHQQQQKNSGTLEERVRALGDRVDCIN
SQLNRVLDSMS
3D structure
PDB6co7 Structure of a TRPM2 channel in complex with Ca2+explains unique gating regulation.
ChainB
Resolution3.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR B V1027 Q1028 Y1031 V889 Q890 Y893
BS02 CA B E893 Q896 N918 D921 E755 Q758 N780 D783
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
GO:0005272 sodium channel activity
GO:0015280 ligand-gated sodium channel activity
GO:0046872 metal ion binding
GO:0047631 ADP-ribose diphosphatase activity
GO:0099604 ligand-gated calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006814 sodium ion transport
GO:0019722 calcium-mediated signaling
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6co7, PDBe:6co7, PDBj:6co7
PDBsum6co7
PubMed29745897
UniProtA7T1N0|TMP2L_NEMVE Transient receptor potential cation channel subfamily M member-like 2 (Gene Name=TRPM2)

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