Structure of PDB 5wzx Chain B

Receptor sequence

>5wzxB (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]

ELTPDQQTLLHFIMDSYNKQRMPQEITNKNFLILTEMATNHVQVLVEFTK
KLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPLEERIRNSGISD
EYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQE
PLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDH
KFTPLLCEIWDV

3D structure

PDB

5wzx Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity

Chain

Resolution

2.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	V312 K316 H326 Q329 I330 K334 L477 E480	V46 K50 H60 Q63 I64 K68 L205 E208
BS02	7VX	B	M341 F342 M378 W467 F474	M75 F76 M106 W195 F202

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity
GO:0032052	bile acid binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0038183	bile acid signaling pathway

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5wzx, PDBe:5wzx, PDBj:5wzx
PDBsum	5wzx
PubMed	29162643
UniProt	Q96RI1\|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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