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BioLiP

Structure of PDB 4z2e Chain B

Receptor sequence
>4z2eB (length=472) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMN
ELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLV
DGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANE
REPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEV
TTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIVVTEF
PYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIRDASANVIL
NNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTR
FDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLS
ERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQI
IKDELDEVKRKFSDKRRTELMV
3D structure
PDB4z2e Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
ChainB
Resolution3.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B A173 G175 A172 G174
BS02 dna B H43 H76 H78 H42 H75 H77
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:4z2e, PDBe:4z2e, PDBj:4z2e
PDBsum4z2e
PubMed
UniProtQ8DPM2|GYRA_STRR6 DNA gyrase subunit A (Gene Name=gyrA)

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