BioLiP

Structure of PDB 4j98 Chain B

Receptor sequence

>4j98B (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]

AGVSEYELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKE
AVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPL
YVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQL
ARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKQT
TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE
ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI
LTLT

3D structure

PDB

4j98 Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.

Chain

Resolution

2.3067 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D626 A628 R630 N631 D644
Catalytic site (residue number reindexed from 1)	D166 A168 R170 N171 D184
Enzyme Commision number	2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ACP	B	L487 G488 E489 G490 A491 A515 Y566 A567 N571 L633 D644	L27 G28 E29 G30 A31 A55 Y106 A107 N111 L173 D184

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

PDB	RCSB:4j98, PDBe:4j98, PDBj:4j98
PDBsum	4j98
PubMed	23871672
UniProt	P21802\|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)