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BioLiP

Structure of PDB 4iqr Chain B

Receptor sequence
>4iqrB (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]
ALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKD
KRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQ
AEVLSDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVAL
LRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRIL
DELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSL
EDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNL
LQEMLLGG
3D structure
PDB4iqr Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex.
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B H62 Y63 K72 R76 R80 Q122 E124 R125 R127 S129 H14 Y15 K24 R28 R32 Q74 E76 R77 R79 S81 PDBbind-CN: Kd=80nM
BS02 dna B D69 G70 R77 R100 N101 R104 R107 R125 I128 D21 G22 R29 R52 N53 R56 R59 R77 I80 PDBbind-CN: Kd=80nM
BS03 peptide B F199 L204 L211 R212 E363 F139 L144 L151 R152 E303
BS04 ZN B C51 C71 C3 C23
BS05 ZN B C87 C93 C103 C106 C39 C45 C55 C58
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:4iqr, PDBe:4iqr, PDBj:4iqr
PDBsum4iqr
PubMed23485969
UniProtP41235|HNF4A_HUMAN Hepatocyte nuclear factor 4-alpha (Gene Name=HNF4A)

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