Structure of PDB 4hxz Chain B

Receptor sequence
>4hxzB (length=284) Species: 376619 (Francisella tularensis subsp. holarctica LVS) [Search protein sequence]
KSIEVLTGLDPVKKRPGMYTNIENPNHLIQEIIDNSVDEVLAGFASKINI
TLYEDNSIEVADDGRGMPVDIHPEHKMSGIELIMTKLHSGGKFSNHGVGV
SVVNALSTRLEAEIKRDGNVYHIVFEDGFKTKDLEIIDNVGKKNTGTKIR
FWPNKKYFDDIKVNFKALKNLLEAKAILCKALTIKYSNEIKKEKLTWHFE
TGLKGYLDHKETLPAEPFIIDNFSNGDSYLDAVFCWNSYVNLIPTPQDGT
HVTGLKNAQLNYVISVKITNPTKEKLSNKDVTNF
3D structure
PDB4hxz Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 19Y B I38 N41 E45 D68 R71 G72 M73 P74 V115 T162 I164 I32 N35 E39 D62 R65 G66 M67 P68 V100 T147 I149
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hxz, PDBe:4hxz, PDBj:4hxz
PDBsum4hxz
PubMed23352267
UniProtA0A0J9WZF0|PARE_FRATH DNA topoisomerase 4 subunit B (Gene Name=parE)

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