BioLiP

Structure of PDB 4hxz Chain B

Receptor sequence

>4hxzB (length=284) Species: 376619 (Francisella tularensis subsp. holarctica LVS) [Search protein sequence]

KSIEVLTGLDPVKKRPGMYTNIENPNHLIQEIIDNSVDEVLAGFASKINI
TLYEDNSIEVADDGRGMPVDIHPEHKMSGIELIMTKLHSGGKFSNHGVGV
SVVNALSTRLEAEIKRDGNVYHIVFEDGFKTKDLEIIDNVGKKNTGTKIR
FWPNKKYFDDIKVNFKALKNLLEAKAILCKALTIKYSNEIKKEKLTWHFE
TGLKGYLDHKETLPAEPFIIDNFSNGDSYLDAVFCWNSYVNLIPTPQDGT
HVTGLKNAQLNYVISVKITNPTKEKLSNKDVTNF

3D structure

PDB

4hxz Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	19Y	B	I38 N41 E45 D68 R71 G72 M73 P74 V115 T162 I164	I32 N35 E39 D62 R65 G66 M67 P68 V100 T147 I149

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006265	DNA topological change

	Cellular Component
GO:0005694	chromosome

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:4hxz, PDBe:4hxz, PDBj:4hxz
PDBsum	4hxz
PubMed	23352267
UniProt	A0A0J9WZF0\|PARE_FRATH DNA topoisomerase 4 subunit B (Gene Name=parE)