Structure of PDB 4htp Chain B

Receptor sequence
>4htpB (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
QTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNH
KDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDAL
KLLNYRTGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKD
LIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELH
NVTTDLEKVCRQLHDPSVGLSD
3D structure
PDB4htp Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining.
ChainB
Resolution2.2502 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V14 D18 S45 F49 V7 D11 S38 F42
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051103 DNA ligation involved in DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4htp, PDBe:4htp, PDBj:4htp
PDBsum4htp
PubMed23219551
UniProtP49917|DNLI4_HUMAN DNA ligase 4 (Gene Name=LIG4)

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