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BioLiP

Structure of PDB 4f5d Chain B

Receptor sequence
>4f5dB (length=188) Species: 9606 (Homo sapiens) [Search protein sequence]
FNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILL
PLDCGVPDNLSMADPNIRFLDKLPQQTADRAGIKDRVYSNSIYELLENGQ
RAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADA
PESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEE
3D structure
PDB4f5d The structural basis for the sensing and binding of cyclic di-GMP by STING
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2E B Y167 I235 R238 Y240 S241 Y15 I83 R86 Y88 S89 BindingDB: EC50=4500nM,Kd=1210nM
BS02 MG B G166 R232 R238 G14 R80 R86
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4f5d, PDBe:4f5d, PDBj:4f5d
PDBsum4f5d
PubMed22728659
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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