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BioLiP

Structure of PDB 4cco Chain B

Receptor sequence
>4ccoB (length=459) Species: 9606 (Homo sapiens) [Search protein sequence]
MSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHFYRRLWEREAVLVR
RQDHTYYQGLFSTADLDSMLRNEEVQFGQHLDAARYINGRRETLNPPGRA
LPAAAWSLYQAGCSLRLLCPQAFSTTVWQFLAVLQEQFGSMAGSNVYLTP
PNSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRAPTEELALTCSPNFSQDD
LGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDF
LEAILPLAVQAAMEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKV
RVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVYGLPIRWE
AGEPVNVGAQLTTETEVHMLQDGIARLVGEGGHLFLYYTVENSRVYHLEE
PKCLEIYPQQADAMELLLGSYPEFVRVGDLPCDSVEDQLSLATTLYDKGL
LLTKMPLAL
3D structure
PDB4cco Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
1.14.11.79: protein-L-histidine (3S)-3-hydroxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R297 L299 M322 G324 N326 F337 H340 D342 C373 T419 S421 Q424 Y577 R116 L118 M141 G143 N145 F156 H159 D161 C192 T238 S240 Q243 Y396
BS02 MN B H340 D342 H405 H159 D161 H224
External links
PDB RCSB:4cco, PDBe:4cco, PDBj:4cco
PDBsum4cco
PubMed24814345
UniProtQ9H6W3|RIOX1_HUMAN Ribosomal oxygenase 1 (Gene Name=RIOX1)

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